Antipsychotic Drug Is Effective in Treating Bipolar Disorder

SEPTEMBER 01, 2004
Susan Farley

In a phase 3, double-blind, multicenter, placebo-controlled trial, the antipsychotic drug aripiprazole (Abilify) was found to safely and effectively treat various aspects of bipolar disorder. Using outcome measurements such as the Young Mania Rating Scale, the Clinical Global Impression Scale?Bipolar Disorder, and the Positive and Negative Syndrome Scale Hostility Subscale, patients taking 30 mg/day of aripiprazole for 1 week showed significant improvements by day 4, compared with patients taking placebo. Patients in both groups showed a difference in body weight, but none was statistically significant. Adverse events?such as dyspepsia, constipation, akathisia, and extremity pain?occurred at least twice as often in the aripiprazole group. The intensity of these events, however, was considered generally mild to moderate. Discontinuation rates were similar in both the aripiprazole group and the placebo group.

Researchers conducted a long-term relapse-prevention study of patients with bipolar disorder receiving aripiprazole. They found that the time until relapse was significantly prolonged among patients in the aripiprazole group. Furthermore, incidence of relapse (manic, mixed, or depressive symptoms) was less in patients treated with aripiprazole. Results showed that only anxiety and nervousness were more common in the aripiprazole group than in the placebo group.



SHARE THIS SHARE THIS
0

Become A RESPIMAT T.O.P. Performer 

Get to know RESPIMAT, the slow-moving mist inhaler from Boehringer Ingelheim Pharmaceuticals, Inc.

Watch the RESPIMAT video and test your knowledge with a short multiple-choice quiz. When you get all the answers right, you’ll receive a certificate naming you a RESPIMAT T.O.P. Performer. Why not check it out today?


Pharmacy Times Strategic Alliance
 

Pharmacist Education
Clinical features with downloadable PDFs


Next-Generation Pharmacist® Awards


3rd Annual Convenient Healthcare and Pharmacy Collaborative Conference


SIGN UP FOR THE PHARMACY TIMES NEWSLETTER
Personalize the information you receive by selecting targeted content and special offers.