Cholesterol Lowering Drug Safe and Effective in Children
JANUARY 01, 2003
The cholesterol-lowering drug sim-vastatin significantly reduced cholesterol levels in children with inherited high cholesterol, according to a randomized study published in Circulation (October 1, 2002). A total of 173 children (aged 9 to 18 years) with inherited high cholesterol were randomized to up to 40 mg of simvastatin or placebo. After 48 weeks, the children who received simvastatin showed a 41% reduction in low-density lipoprotein, a 31% reduction in total cholesterol, a 34% reduction in apolipoprotein B, a 21% reduction in very low-density lipoprotein, and a 9% reduction in triglycerides. The drug did not affect the growth or maturation of the children.
AF Risk Increases with More Pregnancies
One study linked multiple pregnancies to an increased risk of developing atrial fibrillation later in life, and another investigated the association between premature delivery and cardiovascular disease.