Asthma

Benralizumab was previously approved by the FDA in 2017 as an add-on maintenance therapy for patients 12 years and older.

Piezo1 is a protein produced by type 2 innate lymphoid cells when activated by an allergen and can limit the immune cell’s activity when triggered by a reaction.

The Asthma and Allergy Foundation of America applauded the efforts by AstraZeneca, saying accessibility and affordability can help reduce racial disparities in asthma.

The effects were strongest during the spring season and in the third trimester of pregnancy.

Investigators found that 1,1,1 trichloroethane; 2-nitropropane; and 2,4,6 trichlorophenol were significantly associated with asthma symptoms for 3 exposure periods.

The study showed no clinical differences for remission or asthma at age 28 years based on lung function, body mass index, daily smoking, exposure to parental tobacco smoke, or house dampness .

Individuals with persistent asthma and at least 1 complex comorbidity were more likely to use telemedicine, the results of the study showed.

AAO-HNSF guideline development group included 17 panel members, including experts from otolaryngology and allergy, those who have knowledge in clinical practice guideline development, and patient representatives.

Dupilumab (Dupixent; Sanofi) showed greater reductions in mucus plugs and greater improvements in airway volume and flow for individuals with uncontrolled moderate-to-severe asthma.

RSV can exacerbate asthma development by causing damage to the tissue in the airways, promoting inflammation and increasing airway hyper-responsiveness

The efficacy of biologics suggests a potential for biologic-based treatment for patients with asthma-chronic obstructive pulmonary disease overlap.

The new understanding of immune cells could not only contribute to the development of lung disease treatments, but treatments for other organ systems as well.

The study authors note that interventions to reverse frailty, such as screening and assessments to identify issues, can help in the management of COPD and asthma and lead to better prognoses.

The study results demonstrated that 92% of patients treated with benralizumab were able to safely reduce inhaled steroid dose, and more than 60% could stop use entirely.

The study authors note that the Best ACT-S questionnaire complements the Best ACT-P questionnaire, a previously developed questionnaire that assesses preschool-aged patients with asthma.

The study also showcases a significant decline in asthma mortality rates in China, which were previously higher than the United States from 1990 to 2019.

This innovation could be useful for optimizing the collaboration between patients with asthma and their health care providers through remote telemedicine consultations.

The study also found that 82% of the surveyed physicians reported not getting labs to help determine treatment options for their patients.

Compared to the standard prenatal vitamin alone, vitamin D supplementation with the prenatal vitamin reduced the risk of asthma and wheezing in children by approximately 50%.

Preventative drug lists were associated with a modest increase in adherence to combination inhaled corticosteroid long-acting β2-agonists.

CD4+ tissue-resident memory T cells may trigger severe, and potentially fatal, asthma attacks in men aged 40 years and older.

More individuals who used e-cigarettes have reported pulmonary diseases compared with those who never smoked, including asthma.

Investigators created a model to predict asthma exacerbations that can be integrated in WhatsApp chatbot and relies on self-reported data.

Many patients would like more education about managing their asthma, which can help to reduce the overuse of short-acting beta-2 agonists.

Investigators hope that continued research and addressing disparities can improve equitable access to asthma treatments for all pediatric patients.

A workgroup of asthma treatment experts introduced 6 new criteria that those diagnosed with asthma must meet to be in remission.

A patient with lung adenocarcinoma who was treated with an immune checkpoint inhibitor developed symptoms related to asthma and breathing obstruction.

Pediatric and maternal respiratory syncytial virus (RSV) vaccines are being studied to reduce the burden of RSV, and more research is needed to understand whether this can reduce wheeze and asthma.

The upcoming study seeks to analyze whether immature lungs in infants infected with respiratory syncytial virus increases the likelihood of developing asthma later in life.