Commonly Prescribed Acid Reflux Medication Not Helpful for Children With Asthma
Published Online: Friday, July 20, 2012
Acid reflux is common among children with asthma, and in recent years there has been a dramatic increase in prescriptions of proton pump inhibitors (PPIs) for children with asthma. This episode of the JAMA Report discusses a controlled study in which pediatric asthma patients without acid reflux symptoms were given either placebo or a PPI in addition to corticosteroids. The study found that PPI treatment did not improve asthma symptoms and may come with risks, including increased chance of infection.
In a recent phase 2b study, patients with asthma reported reduced exacerbations and improved lung function after receiving dupilumab, an investigational therapy from Sanofi-Aventis and Regeneron Pharmaceuticals Inc.