Clopidogrel Less Effective in Patients with Diabetes

Published Online: Friday, October 5, 2012
Follow Pharmacy_Times:
Patients with diabetes have a significantly diminished relative effectiveness of platelet inhibition with clopidogrel (Plavix) following myocardial infarction when compared with patients without diabetes.

Scientists led by Charlotte Andersson, MD, PhD, of Gentofte Hospital in Hellerup, Denmark, analyzed 58,851 patients who were hospitalized with incident heart attack, 12% of whom had diabetes, and 60% of whom were treated with clopidogrel. They found that nondiabetic clopidogrel users achieved a significant 23% reduction in cardiovascular mortality, whereas patients with diabetes only achieved a nonsignificant 7% reduction in risk.

In an editorial accompanying the September 5, 2012, article in the Journal of the American Medical Association, Deepak Bhatt, MD, MPH, noted that the reason diabetics do not benefit from clopidogrel as much as other patients is that compared with nondiabetics, diabetics with coronary artery disease have heightened platelet reactivity.

Despite its lower efficacy in preventing secondary heart attack, those patients with diabetes who took clopidogrel had lower crude incidence rates of all-cause mortality than those who were not taking the drug, and authors of the study maintain that clopidogrel may still be worthwhile for patients with diabetes.

Related Articles
The lack of generic insulin may keep patients from using the medicine, even though they risk life-threatening complications, new research from Johns Hopkins University School of Medicine suggests.
An FDA advisory panel recommends adding a warning about the potential risk for heart failure to the labels of saxagliptin (Onglyza), saxagliptin/metformin (Kombiglyze), and alogliptin (Nesina).
The FDA refused to approve Novo Nordisk’s ultra-long-acting insulin treatments 2 years ago.
The FDA has approved GlaxoSmithKline’s Tanzeum (albiglutide) subcutaneous injection as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
Latest Issues
  • photo
    Pharmacy Times
    photo
    Health-System Edition
    photo
    Directions in Pharmacy
    photo
    OTC Guide
    photo
    Generic Supplements
  • photo
    Pharmacy Careers
    photo
    Specialty Pharmacy Times
    photo
    Generic
$auto_registration$