Weight Loss Shown Not to Decrease Risk of Diabetes-Associated Cardiovascular Events

Published Online: Friday, November 9, 2012
Follow Pharmacy_Times:
Despite the fact that many new studies have shown that weight loss cuts diabetes risk, and may even reduce several risk factors for cardiovascular disease, a new study from the National Institutes of Health (NIH) reveals that weight loss does not lower the risk of heart disease in people who already have type 2 diabetes.

The Look AHEAD (Action for Health in Diabetes) study enrolled 5145 patients with diabetes aged 45 to 76 years across 16 research centers. Half of participants were assigned to receive an intensive lifestyle intervention geared toward weight loss and the other half participated in a general diabetes support program. Researchers sought to determine if an intense weight loss program would help the intervention group lower its risk of heart disease, stroke, and cardiovascular events.

The study was halted in September 2012 because an independent advisory board found that although the intervention arm did not cause harm, the intensive lifestyle modifications did not decrease the occurrence of cardiovascular events.

“Both groups had a lower number of cardiovascular events compared to previous studies of people with diabetes,” however, according to Mary Evans, PhD, director of special projects in nutrition, obesity, and digestive diseases within the NIH’s National Institute of Diabetes and Digestive and Kidney Diseases.


Related Articles
Jennifer Goldman, PharmD, CDE, BC-ADM, FCCP, professor of pharmacy practice at MCPHS University, discusses the role pharmacists can play when helping clinicians overcome barriers to initiating insulin use.
Ranibizumab (Lucentis), a prescription drug frequently used to treat age-related vision loss, can also improve vision in patients with diabetic retinopathy and diabetic macular edema, a recent study indicated.
The advantages offered by insulin pens may help improve patient adherence.
Latest Issues
  • photo
    Pharmacy Times
    photo
    Health-System Edition
    photo
    Directions in Pharmacy
    photo
    OTC Guide
    photo
    Generic Supplements
  • photo
    Pharmacy Careers
    photo
    Specialty Pharmacy Times
    photo
    Generic
$auto_registration$