Hyperglycemia Associated with Arterial Stiffness

Published Online: Friday, December 14, 2012
Follow Pharmacy_Times:
Hyperglycemia is not only associated with an increased risk of atherosclerosis, but may also be an independent risk factor for hardened arteries, according to a study published in the November 2012 issue of Atherosclerosis.

The researchers looked at 9050 participants from the community-based Atherosclerosis Risk in Communities Study. Participants included both diabetic and nondiabetic patients. Researchers examined each participant’s carotid artery using ultrasounds and analyzed the association between hyperglycemia, as measured by A1C levels, and arterial stiffness. Stiffness was measured using 2 common indicators: pressure–strain elastic modulus (Ep) and Young’s elastic modulus (YEM). Researchers also interviewed participants for demographic and lifestyle information, including age, sex, race, alcohol use, smoking status, and family history of diabetes.

Higher A1C levels were associated with increased arterial stiffness for both Ep and YEM. Researchers suggest that hyperglycemia contributes to arterial stiffness beyond its effects on atherosis. The study suggests that hyperglycemia may be associated with altered material within the arterial wall and not with wall thickness or increased blood pressure.

Related Articles
The FDA has approved the intravitreal implant, Iluvien 0.19 mg, as the first long-term treatment for diabetic macular edema.
Pharmacists who participate in community-based diabetes care teams play a pivotal role in reducing A1C levels among patients with poorly controlled diabetes.
The dexamethasone intravitreal implant, Ozurdex, is now indicated to treat all patients with diabetic macular edema.
The FDA has cleared the Nova StatStrip Glucose Hospital Meter System to become the first blood glucose monitoring system for use in critically ill patients who have been hospitalized.
Latest Issues
$auto_registration$