Alendronate Is Safe with NSAIDs

MAY 01, 2005

Oral bisphosphonates such as alendronate and nonsteroidal anti-inflammatory drugs (NSAIDs) can irritate the upper gastrointestinal (GI) tract and damage the intestinal mucosa. Frequently, the same patient population concomitantly uses both types of treatment. B. Cryer, MD, and colleagues addressed the concern over potential additive effects and the likelihood of damage in patients taking concomitant NSAIDs and alendronate (70 mg/wk) in a 12-week, double-blind, placebo- controlled study of 450 patients. The results of the study, reported in Alimentary Pharmacology and Therapeutics (March 2005), showed no significant difference in upper GI adverse events (AEs) among NSAID users receiving concomitant alendronate (n = 118) or placebo (n = 104).

Similarly, no significant differences in AEs were noted between those who were and those who were not also taking a gastroprotective agent (eg, a proton pump inhibitor or a histamine2 antagonist). In addition, there was no significant difference in upper GI AEs in patients taking a cyclooxygenase- 2-specific NSAID, compared with a nonspecific NSAID. The authors concluded that there is no increase in upper GI AEs with concomitant use of once-weekly alendronate and NSAIDs.



SHARE THIS SHARE THIS
0

Become A RESPIMAT T.O.P. Performer 

Get to know RESPIMAT, the slow-moving mist inhaler from Boehringer Ingelheim Pharmaceuticals, Inc.

Watch the RESPIMAT video and test your knowledge with a short multiple-choice quiz. When you get all the answers right, you’ll receive a certificate naming you a RESPIMAT T.O.P. Performer. Why not check it out today?


Pharmacy Times Strategic Alliance
 

Pharmacist Education
Clinical features with downloadable PDFs


Next-Generation Pharmacist® Awards


3rd Annual Convenient Healthcare and Pharmacy Collaborative Conference


SIGN UP FOR THE PHARMACY TIMES NEWSLETTER
Personalize the information you receive by selecting targeted content and special offers.