Pharmacy Times

A Therapeutic Option for the Management of Gastroesophageal Reflux Disease


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The prevalence of gastroesophageal reflux disease (GERD) in the United States has been estimated at 18.6 million diagnosed cases, based on 1998 research.1 A review of recent studies conducted in US and non-US populations with GERD-related symptoms estimated that approximately 20% to 40% of patients with GERD have erosive esophagitis (EE) from acid-related mucosal injury, whereas 50% to 70% have nonerosive disease.2 According to the National Institutes of Health, the total cost of GERD in 2004 was $12.6 billion; direct costs accounted for $12.1 billion and indirect costs for $0.5 billion.3

GERD is a complex disease process characterized by a disruption in the body’s mechanisms to protect the esophagus from reflux of acid and other gastric contents. It may result from abnormally weak contractions of the lower esophageal sphincter (LES) or from transient LES relaxations, which allow gastric content to flow upward into the esophagus.4,5 GERD is defined by frequent and persistent troublesome symptoms, the most common being heartburn. Some patients have acid-related damage (erosions), such as mucosal breaks or lesions, to the lining of the esophagus known as EE, relating to the abnormal reflux of gastric content.4,5

The majority of patients diagnosed with GERD have the symptoms of GERD, including heartburn, without having EE.4-6 This is known as nonerosive symptomatic GERD. In clinical practice, patients with nonerosive symptomatic GERD are considered a heterogeneous group; the degree to which their symptoms correlate with actual episodes of gastroesophageal acid reflux varies. In addition, symptoms do not always reflect the extent or severity of disease.4,5

Physicians may recommend that patients with GERD implement diet and lifestyle changes such as reducing meal size and fat intake and avoiding trigger foods.4,5,7 Despite diet and lifestyle modifications, symptoms persist in many patients with GERD.7 For those patients, additional evaluation is warranted and pharmacologic therapy may be an option.7

Proton Pump Inhibitors For GERD
The proton pump inhibitor (PPI) class of drugs is the most widely used first-line therapy for GERD. PPIs reduce gastric acid secretion and increase gastric pH by inhibiting the hydrogen-potassium–activated ATPase proton pump, or (H ,K )-ATPase, the enzyme system of the gastric parietal cell that activates gastric acid production and maintains stomach acidity.4,5 PPIs effectively suppress acid secretion and provide EE healing and symptom relief in many patients with GERD.4




 
Important Safety Information

Please see link to prescribing information for Dexilant below.

Administration Information
Dexlansoprazole can be taken without regard to food. If postmeal symptoms do not resolve, however, some patients may benefit from dose administration prior to a meal.8 In a recent study in healthy subjects evaluating dexlansoprazole administration prior to breakfast, lunch, dinner, or evening snack, dexlansoprazole provided comparable acid suppression when taken at different times of the day.9 The capsule should be swallowed whole. Alternatively, capsules may be opened and the granules sprinkled on a tablespoon of applesauce and immediately swallowed.8 Granules should not be chewed. Do not store for later use.

 

 

DEXILANT and DEXILANT (with design) are trademarks of Takeda Pharmaceuticals North America, Inc., registered in the U.S. Patent and Trademark Office and used under license by Takeda Pharmaceuticals America, Inc.

Dual Delayed Release is a trademark of Takeda Pharmaceuticals North America, Inc. and used under license by Takeda Pharmaceuticals America, Inc.

 


For Full Prescribing Information, click here.

 

References

1. Sandler RS, Everhart JE, Donowitz M, et al. The burden of selected digestive diseases in the United States. Gastroenterology. 2002;122:1500-1511.
2. Fass R. J Clin Gastroenterol. 2007;41:131-137.
3. Ruhl CE, Sayer B, Byrd-Holt DD, Brown DM. Costs of digestive diseases. In: Everhart JE, ed. The burden of digestive diseases in the United States. US Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases. Washington, DC: US Government Printing Office, 2008; NIH Publication No. 09-6443 pp. 137-147.
4. Saltzman JR, Poneros JM. Gastroesophageal Reflux Disease. In: Greenberger NJ, Blumberg RS, Burakoff R, eds. Current Diagnosis & Treatment: Gastroenterology, Hepatology, & Endoscopy. New York, NY: The McGraw-Hill Companies, Inc; 2009:139-147.
5. Hasler WL. In: Fauci AS, Kasper DL, Longo DL, et al, eds. Harrison’s Principles of Internal Medicine. 17th ed. New York, NY: The McGraw-Hill Companies, Inc; 2008:240-245.
6. Savarino V, Savarino E, Parodi A, Dulbecco P. Dig Dis. 2007;25:172-174.
7. DeVault KR, Castell DO; American College of Gastroenterology. Am J Gastroenterol. 2005;100:190-200.
8. DEXILANT [package insert]. Deerfield, IL: Takeda Pharmaceuticals America, Inc; 2011.
9. Lee RD, Mulford D, Wu J, Atkinson SN. The effect of time-of-day dosing on the pharmacokinetics and pharmacodynamics of dexlansoprazole MR—evidence for dosing flexibility with a Dual Delayed Release proton pump inhibitor. Aliment Pharmacol Ther. 2010;31:1001-1011.


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