Author: Martin A. Erickson III, RPh
Mr. Erickson is director of professional affairs at Gallipot Inc.
Loxapine suspension is not available. How can I
compound the suspension for a patient?
Loxapine is an anxiolytic. Loxapine 1 mg is provided
by Loxapine succinate 1.36 mg or loxapine HCl
1.12 mg. The latter is no longer available in the United
States. The starting adult dose is 10 mg twice daily in psychoses
and may be increased in the first 7 to 10 days of therapy;
usual maintenance doses are 60 to 100 mg daily, divided
into 2 to 4 doses. Absorption, distribution, and effects are
nearly identical regardless of route, and first-order degradation
of loxapine succinate should approximate that of loxapine
HCl; therefore, it is reasonable to suggest compounding loxapine
succinate suspension for oral administration.
Loxapine Succinate Oral Suspension/Solution
qs ad 100%
- Calculate the number of capsules required to provide loxapine
equivalent for the preparation. Note: Capsules contain
excipients; consider the equivalences above. [Source:
American Hospital Formulary Service Drug Information 2007].
- Accurately weigh/measure ingredien
into a weigh boat.
- Reduce powder to fine, uniform consistency with ceramic
or Wedgwood mortar and pestle (not glass).
- Add a small amount of SyrSpend SF to (3) and triturate to
a smooth paste.
- Continue adding aliquots of SyrSpend SF to the paste (4),
triturating until approximately half of the total for the
preparation is incorporated.
- Transfer the smooth, homogeneous suspension (5) to a
graduated cylinder, using small amounts of SyrSpend SF to
?wash? the mortar and pestle contents into the graduate.
- Add sufficient SyrSpend SF to the graduated cylinder in
(6) to reach total final volume.
- Transfer to light-resistant dispensing bottle. Label: Shake
well and Refrigerate.
Beyond-Use Date: 14 days, per USP <795>
E-mail your compounding questions to .