Pharmacy Times

compounding HOTLINE

Author: Martin A. Erickson III, RPh

Mr. Erickson is director of professional affairs at Gallipot Inc.

Do you have a formulation for extemporaneous preparation of prednisolone suspension? I have a pediatric patient who cannot tolerate the manufactured preparation.

Prednisolone Sodium Phosphate Oral Solution #1 (sugar-free, alcohol-free, dye-free) Calculated to make 100 mL

Prednisolone sodium phosphate 0.135 g
Sorbitol 70% USP 50.0 mL
Sodium saccharin 0.500 g
*Flavor concentrate 1.0 mL
Distilled water USP qs ad 100.0 mL
*Raspberry, strawberry, or cherry.

Balance with weights and weigh paper or weigh boats
Graduated cylinder
Mortar and pestle
Stirring rod


  1. Dissolve the prednisolone sodium phosphate and the sodium saccharin in 40 mL of distilled water.
  2. Add the sorbitol 70% USP and flavor concentrate to (1) with stirring.
  3. Add sufficient distilled water to (2) to make 100 mL.

Notes: No claims are made as to the uses, safety, efficacy, or bioavailability of this product.

The formula is for informational purposes only.

E-mail your compounding questions to .