Proton pump inhibitors (PPIs) effectively suppress stomach acidity and are widely used in treating gastroesophageal reflux disease and related conditions. Omeprazole and other PPIs, however, can delay gastric emptying. In a study published in Alimentary Pharmacology & Therapeutics (July 2005), Gervais Tougas, MD, FRCPC, et al tested the hypothesis that treatment with tegaserod normalizes or prevents omeprazole-induced delayed gastric emptying. For the study, 40 healthy men were treated with omeprazole (20 mg bid) and either tegaserod (6 mg tid) or placebo for 14 days. Gastric emptying was assessed by scintigraphy before and after treatment.
Omeprazole monotherapy significantly delayed gastric emptying expressed by duration of lag phase (P < .007), time to gastric half-emptying (P < .003), and gastric retention of the meal at 60 minutes (P < .002) and 120 minutes (P < .04) after ingestion. Combination therapy with tegaserod and omeprazole safely and effectively prevented the development of delayed gastric emptying induced by omeprazole.