A recent study that gene-targeted mice found that good cholesterol may be generated in the liver. In an effort to find clues to the rare Tangier disease, in which affected people are unable to produce high-density lipoprotein (HDL), researchers found that the liver is the source of 80% of HDL.
Scientists had previously believed that HDL was formed throughout the body, particularly in the blood vessel walls. This new finding could lead the way for a variety of drugs to be developed. Besides Tangier disease, low HDL is associated with a higher risk of heart attack.