A recent study, the results of which were reported in Diabetes Care, found that Transdermal L-Arginine cream improved impaired blood flow in the feet of patients with diabetes. The cream enhanced circulation by 33% in the metatarsal region and by 35% at the Achilles tendon. Also, the cream increased temperature by 5?F at the metatarsal and by 8?F at the big toe.
L-Arginine is an amino acid that is the biochemical precursor of nitric oxide. Nitric oxide controls local blood flow by relaxing the smooth muscle lining of blood vessels.