Pharmacy Times

Compounding a hydroxyurea liquid

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Do you have any suggestions for compounding a hydroxyurea liquid? The problem is that a child with sickle cell anemia needs a 600-mg dose, and only a 500-mg dose is available. With this patient, 500 mg is ineffective, and 1000 mg makes her sick.
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Hydroxyurea is hygroscopic and decomposes in the presence of moisture. Although it is freely soluble in water,it does not lend itself to the preparation of an oral solution for a pediatric patient. You might want to make powder papers or capsules, to be opened and mixed with liquid immediately before administration.