Lauren S. Schlesselman, PharmD
Dr. Schlesselman is an assistant clinical professor at the University of Connecticut School of Pharmacy.
CASE ONE
TG, a fourth professional–year pharmacy student, is
completing an experiential
rotation at a resort infirmary
pharmacy. A first-professional-year pharmacy student
approaches the pharmacy
counter, asking what OTC
product TG would recommend to alleviate her sunburn. TG
notices that the student has visible first-degree sunburn on
her face. She also has second-degree blisters on her arms
and legs. When TG questions her about the sunburn, she
explains that she developed the sunburn while there on
vacation for spring break. She insists that she applied sun
protection factor 30 sunscreen each day and would reapply
the sunscreen throughout the day. She claims that she usually
develops a suntan easily and rarely burns.
With approval of the pharmacist, TG recommends the student
use ibuprofen 3 times a day to alleviate her sunburn.
When TG rings up the ibuprofen, the student asks if she can
also pick up her prescription, which was transferred here because
she wanted to stay a few days longer and did not bring
enough medication. TG retrieves her prescription for doxycycline.
When TG asks if the student has been taking the doxycycline
while on vacation, she replies that she has faithfully
taken the prescription to control her acne. TG suddenly realizes
that the student's sunburn may be caused by the doxycycline
therapy. When TG explains this, the student wants to
know if she should discontinue the doxycycline. How should
TG respond?
CASE TWO
TH is a 35-year-old woman
who is newly diagnosed with
type 2 diabetes mellitus. She
arrives at the clinic for a follow-up appointment. While
reviewing her chart, the
pharmacist notices that both
of TH's parents have a history
of hypertension. Considering
this family history, the pharmacist decides to check
TH's blood pressure. Her blood pressure is 140/80 mm Hg.
The pharmacist knows that, according to the Seventh
Report of the Joint National Committee on Prevention,
Detection, Evaluation, and Treatment of High Blood Pressure
(JNC 7) guidelines, the blood pressure goal for a patient with
diabetes is <130/80 mm Hg.
After initiating lifestyle changes to attempt to control her
blood pressure, TH returns to the clinic for a follow-up visit
2 months later. At this appointment, her blood pressure is
138/88 mm Hg. The pharmacist is concerned that TH has not
reached her goal blood pressure even though she is still
classified as having prehypertension.
Is TH a candidate for medication therapy despite only
being classified as having prehypertension?
ANSWERS
CASE ONE:
Photosensitivity reactions are known to occur with doxycycline. Photosensitivity reactions appear to be phototoxic in
nature due to accumulation in the skin. These reactions are more severe and more frequent with demeclocycline, but photosensitivity can occur with
tetracycline and doxycycline. Photosensitivity develops within minutes to hours after sun exposure. The primary treatment is discontinuance of doxycycline
therapy. The reaction will persist 1 to 2 days after discontinuance of the causative agent.
CASE TWO:
TH is a candidate for medication therapy because she has diabetes. According to the JNC 7 guidelines, patients with prehypertension
who also have diabetes and/or kidney disease should be considered candidates for appropriate drug therapy if a trial of lifestyle modification fails to
reduce their blood pressure to 130/80 mm Hg or less.