Treating the increase
in drug-resistant
and potentially
deadly bacterial infections,
particularly
methicillin-resistant
Staphylococcus aureus, may not be so
easy. A major problem is that the pipeline
for antibiotics is dwindling.
The Infectious Diseases Society of
America indicated there were 16 new antibiotics
approved by the FDA between 1983
and 1987, and 14 between 1988 and 1992,
totaling an average of 3 a year. In the past 15
years, those figures have been steadily
declining with only 5 new antibiotics getting
FDA approval between 2003 and today.
Why the lack of new drugs? The pharmaceutical
manufacturers are facing higher
costs for new drugs that do not bring in the
money when they enter the market.
Therefore,the companies are investing funds
in other types of medications for profits,
including chronic diseases.
A new report, however, from the
Pharmaceutical Research and Manufacturers
of America found that pharmaceutical
companies are currently testing
338 new drugs to help treat infectious disease,
including 11 medicines and 4 vaccines
to treat staphylococcal infections.
The new medicines being tested are 146
vaccines to prevent diseases such as
smallpox and staph; 83 antibiotics/antibacterials to treat infections such as
pneumonia and tuberculosis; 75 antivirals
to treat such viruses as hepatitis and
influenza; and 25 antifungals.