Anna D. Garrett, PharmD, BCPS, CPP
Researchers are currently studying the possible
anticancer effects of aspirin. Aspirin
blocks cyclooxygenase (COX), which helps
restrict the blood supply to tumors, thereby
limiting tumor growth. The studies of aspirin
involved exposing blood vessel cells to aspirin
or COX-2 inhibitors like celecoxib. Aspirin at
high doses caused death of the blood vessel
cells. This effect was not seen with standard
doses of aspirin or with COX-2 inhibitors.
Investigators plan to continue studying the
underlying mechanism of aspirin's effect in
order to identify new targets for cancer drugs.
Dr. Garrett is a clinical pharmacist
practitioner at Cornerstone Health Care
in High Point, NC.